General Information

  • ID:  hor000337
  • Uniprot ID:  Q94742
  • Protein name:  Scg-AST-5
  • Gene name:  NA
  • Organism:  Schistocerca gregaria (Desert locust) (Gryllus gregarius)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GRLYSFGL
  • Length:  8(196-203)
  • Propeptide:  MGMTSRSSSSEAARLPLPALVLLLLCTSPATPQEVPGDAMTGGGPASAPVSTASEAAAASPPGSASTGAAPMDAESEYDLYKRLCDFGVGKRAYTYVSEYKRLPVYNFGLGKRATGAASLYSFGLGKRGPRTYSFGLGKRGDDEPNDYSEQELFADVDGDSEDALPVAVEADERELPEAAEEEMPGVFTELMDKRGRLYSFGLGKRARPYSFGLGKRAGPAPSRLYSFGLGKREGRMYSFGLGKRPLYGGDRRFS
  • Signal peptide:  MGMTSRSSSSEAARLPLPALVLLLLCTSPATP
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It show potent inhibitory effects on juvenile hormone (JH) biosynthesis by corpora allata (CA) of the cockroach Diploptera punctata
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q94742-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000337_AF2.pdbhor000337_ESM.pdb

Physical Information

Mass: 103709 Formula: C43H65N11O11
Absent amino acids: ACDEHIKMNPQTVW Common amino acids: GL
pI: 9.35 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: 37.5 Boman Index: -376
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 97.5
Instability Index: 875 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  8902848
  • Title:  Isolation and Characterization of Eight Myoinhibiting Peptides From the Desert Locust, Schistocerca Gregaria: New Members of the Cockroach Allatostatin Family